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학술발표회초록보기

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제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 The size and shape effect on amyloid β assemblies

등록일
2012년 2월 21일 16시 22분 06초
접수번호
1311
발표코드
INOR.P-248 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
무기화학
저자 및
공동저자
김유나, 남좌민
서울대학교 화학부, Korea
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting large number of the aging population. The major clinical manifestation of AD is memory loss resulting in behavioral deficits, disorientation in time and space, and impairments in language skills. It is widely accepted that AD results from amyloid-β accumulation in extracellular regions and neurofibrillary tangles in neurons. In the presence of amyloid-β accumulation surrounded by degenerating neurites, these abnormal deposits would be the source of some neurotoxic effect. Here, we designed and realized a model system that allows a systematic study on amyloid β deposition and its toxicity to neuron cells. In this system, the supported lipid layer (SLB) was used as a substrate that mimics in-vivo-like neuron cell membrane environment. On the SLB, amyloid-β assemblies were induced by injecting spherical Au nanoparticles (AuNPs) and Au nanorods (AuNRs), and then neuroblastoma cells were seeded for the neurotoxicity test. The size and shape (aspect ratio for AuNRs in this case) effects on the formation of various amyloid β aggregates were studied on this template using dark-field light scattering from Au nanostructures.

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