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학술발표회초록보기

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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Identification of Degradation Products of Lincomycin and Iopromide by Electron Beam Using LC-MS/MS

등록일
2012년 2월 22일 16시 47분 43초
접수번호
1354
발표코드
ANAL.P-624 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
분석화학
저자 및
공동저자
함현선, 명승운
경기대학교 화학과, Korea
In recent years, pharmaceuticals in the environment are of growing concern and scientific interest worldwide. Identification of degradation products of pharmaceuticals is a challenging task because they are present in very low concentrations. It is led to need for the development of its metabolites and degradation products, as well as parent pharmaceuticals. Identification of the degradation products of lincomycin (antibiotic pharmaceuticals) and iopromide (iodinated X-ray contrast media (ICM)) under electrical beam was performed by LC-MS/MS. Electron beam (10 MeV, 1 mA and 10 kW) experiments for the spiked aqueous sample, which in fortified with lincomycin and iopromide, were performed at the dose of 10 kGy. The separation of its degradation products, lincomycin and iopromide was carried by C18 column (2.1 × 100 mm, 3.5 μm and 4.6 × 100 mm, 3 μm, respectively), using gradient elution with 20 mM ammonium acetate or 0.1% formic acid and acetonitrile. Some degradation products of lincomycin and iopromide were identified by interpretation of mass spectra by mass spectrometry.

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