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학술발표회초록보기

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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Drug release monitoring from monodisperse drug-loaded PLGA microparticles using lanthanide ligand-sensitized fluorescence

등록일
2012년 2월 22일 17시 00분 33초
접수번호
1360
발표코드
ANAL.P-629 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
분석화학
저자 및
공동저자
김경민, 이상학, 김환곤1
경북대학교 화학과, Korea
1경북대학교 기계공학부, Korea
A drug release monitoring method has been presented for the determination of two model drugs, L-dopa (LD) and enoxacin (ENX), which released from monodisperse drug-loaded polylactic-co-glycolic acid (PLGA) microparticles prepared by solvent evaporation technique using a microfluidic chip device. The presented method is more sensitive and selective than the conventional UV-Vis absorption method since the highly enhanced fluorescence (FL) emission of Tb(III) at 544 nm is induced by ligand-sensitized effect of the LD and ENX. The FL enhancement showed a good linear relationship with the concentration of two model drugs. The effects of Tb(III) concentration and pH were investigated and optimized for the drug release monitoring as well as the determination of LD and ENX using a standard calibration curve. Drug release profiles from monodisperse PLGA microparticles were investigated and compared with UV-Vis detection method. The results of relationship between PLGA particle concentration and FL intensity showed that the proposed method is reliable and precise to monitor drug release.

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