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학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Mussel-Inspired Instant Medical Adhesives Using Fe3+ Ion-Mediated Rapid Crosslinking for Immobilizing Drug-Loaded Polymeric Patch

등록일
2012년 2월 23일 09시 49분 02초
접수번호
1384
발표코드
POLY.P-76 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
고분자화학
저자 및
공동저자
유지현
KAIST 나노과학기술대학원, Korea

Metal-ion based polymer hydrogel is an emerging tissue engineering material adhesives because of its reversibility and self-healing properties upon crosslinking by coordination bonds. Bio-inspired by mussel curticle cohesion, rapid curing catechol-functionalized hyaluronic acid and chitosan based medical adhesives were synthesized to immobilize a polymeric patch via iron-mediated crosslinking. Catechol groups were first introduced on hyaluronic acid and chitosan, and both were cross-linked with Fe3+ ions respectively. The instantaneous Fe3+-mediated cross-linking which are strong binding affinity with catechol groups and redox activity of Fe3+ ions in longer times, and anchorage effects could contribute the high elastic modulus values and adhesion forces of hydrogels. In addition, amine and carboxylic acid groups in polymer backbone could affect the mechanical properties such as stability of hydrogels. Furthermore, these hydrogels could immobilize the polycarprolactone film on mouse peritoneal region. Thus, these Fe3+-mediated medical adhesives have enormous potential to apply medical applications as drug delivery, tissue engineering and tissue adhesives.


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