abs

학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 The plasma membrane redox system and ageing intervention

등록일
2012년 2월 23일 11시 10분 07초
접수번호
1401
발표코드
BIO1-2 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 15시 : 05분
발표형식
심포지엄
발표분야
생명화학 - Reactive oxygen species in age-related diseases
저자 및
공동저자
현동훈
이화여자대학교 생명과학과, Korea
Oxidative stress over time leads to the accumulation of damaged macromolecules and to profound physiological changes that are associated with age-related diseases including neurodegenerative diseases. The plasma membrane redox system (PMRS) appears to play a protective role during mitochondrial dysfunction to provide cells with a survival mechanism by lowering oxidative stress. The PMRS accomplishes this by producing more NAD(+) for glycolytic ATP production via transfer of electrons from intracellular reducing equivalents to extracelluar acceptors. Activities of PMRS enzymes were selectively decreased in the PM from the hippocampus and cerebral cortex of 3xTgAD mice, an animal model of AD. However, they were elevated by caloric restriction (CR), a manipulation that protects the brain against aging and disease. A higher NAD(+)/NADH ratio and activation of adaptive stress response pathways are enhanced by the PMRS in neuroblastoma cells, enabling them to maintain redox homeostasis under conditions of energetic and proteotoxic stress. These findings have implications for the development of therapeutic interventions for neural tumors and neurodegenerative conditions.

상단으로