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제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Effect of Electrospun Non-woven Mat of Dibutyryl chitin/Poly(lactic acid) Blend on Wound Healing in Hairless mice

등록일
2012년 2월 23일 11시 25분 10초
접수번호
1408
발표코드
ORGN.P-940 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
황희민, 이덕희1, 채규윤2
원광대학교 생명나노화학, Korea
1원광대학교 생명나노화학과, Korea
2원광대학교 화학과, Korea
The aim of this study was to examine the proliferative ability of dibutyryl chitin (DBC) on scratch wound in HaCaT keratinocytes and to evaluate the effect of nanoporous non-woven mat (DBCNFM) on skin wound healing in hairless mice by use of advantages of DBCNFM, such as high porosity and high surface area to volume. The cell spreading activity of DBC was verified through a cell spreading assay in scratched human HaCaT keratinocytes. Scratch wound experiments showed that DBC notably accelerates the spreading rate of HaCaT keratinocytes in dose dependent. The molecular aspects of the healing process were also investigated by hematoxylin & eosin staining of the healed skin, displaying the degrees of reepithelialization and immunostaining on extracellular matrix synthesis and remodeling of the skin. Topical application of DBCNFM significantly reduced skin wound rank scores and increased the skin remodeling of the wounded hairless mice in dose dependent. Furthermore, DCENFM notably increased the expression of the type 1 collagen and filaggrin. These results demonstrate that DBC efficiently accelerates the proliferation of HaCaT keratinocytes and DBCNFM notably increases extracellular matrix synthesis on remodeling of the skin, and these materials are a good candidate for further evaluation as an effective wound healing agent.

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