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학술발표회초록보기

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제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 In vivo chemotherapeutic application of anticancer drug encapsulated layered double hydroxides

등록일
2012년 2월 23일 11시 34분 28초
접수번호
1411
발표코드
MAT.P-1188 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
재료화학
저자 및
공동저자
최고은, 최진호
이화여자대학교 화학.나노과학과, Korea
Drug delivery systems have been intensively studied in the last few decades because they enable drugs to be effectively delivered to target sites, and increase the therapeutic efficacy with minimum side effects through controlled release manner. In this study, an anticancer drug, methotrexate (MTX), has been successfully encapsulated into layered double hydroxides (LDHs) through co-precipitation route to produce MTX-LDH nanohybrids. According to the Powder X-ray diffraction (PXRD), spectroscopy analysis and thermogravimetric analysis, MTX molecules are stabilized in the interlayer space of LDHs by electrostatic interaction, maintain their functional groups and structural integrity. We also investigated the anti-tumor effect of MTX-LDH nanohybrid in orthotopic breast cancer model, and found that the drug efficacy of MTX-LDH was more significantly increased than that of MTX only.

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