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제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Bio-compatible Ca/Fe Layered Double Hydroxides

2012년 2월 23일 12시 09분 43초
MAT.P-1190 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 25일 (수요일) 18:00~21:00
저자 및
Ahmad Imran, 양재훈, 최진호
이화여자대학교 화학.나노과학과, Korea
Inherent chemical inertness along with the safety and stability of hydrotalcite-type layered double hydroxides (LDHs) in the bio-system make them promising candidates for pharmaceutical applications such as the development of drug delivery system (DDS) with controlled release and sustained drug activity. The potential cellular toxicity of various LDHs has been reported in recent decades. However, cytotoxicity study of hydrocalumite-type calcium-based layered anionic clays has not been reported. In this study, we have synthesized nitrate and chloride forms of hydrocalumite-type Ca/Fe LDH by conventional co-precipitation route and evaluated the cytotoxicity of them. Thus prepared hydrocalumite-type Ca/Fe LDHs were physico-chemically characterized with X-ray diffraction (XRD) analysis, fourier transform infrared (FT-IR) spectroscopic analysis and thermo-gravimetric (TG/DT) analysis. XRD patterns of the prepared Ca/Fe LDHs showed the basal spacings of 0.87 and 0.78 nm for chloride and nitrate forms respectively. Morphological examinations by scanning electron microscopy (SEM) and tunneling electron microscopy (TEM) revealed typically plate-like particles with numerous small and regularly well-defined hexagon shaped crystals. To evaluate the toxicological effect of these synthesized Ca/Fe LDHs in vitro, two different cell lines: human normal lung cells (L-132) and HeLa cells are used. Both the forms of Ca/Fe LDHs have no substantial cytotoxicity in terms of inflammation response, oxidative stress, and membrane damage.