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제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 A Novel Thermo-Responsive Microspheres Design for Controlled Drug Release

등록일
2012년 2월 23일 14시 20분 42초
접수번호
1430
발표코드
MAT.P-1191 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
재료화학
저자 및
공동저자
박소현, 장정호1
한양대학교 신소재공학과, Korea
1한국세라믹기술원 바이오IT융합센터, Korea
We report a new drug delivery system by bioabsorbable calcium phosphate (CaP) microspheres and thermo-responsive Poly(N-isopropylacrylamide). The drug delivery system was core-shell type PNIPAm coated CaP microspheres. CaP microspheres were prepared enzymatic decomposition of urea and accomplished by emulsification process (water-in-oil). The prepared CaP microspheres were coated with SiO2 in order to stabilize weak structures and easy functionalization. PNIPAm grafted silica coated CaP microspheres (PNIPAm/SiCaP microspheres) were synthesized by using 3-MOP as a silane coupling agent to introduce double bond onto silica coated CaP microspheres and the radical copolymerization of MOP-SiCaP microspheres and NIPAm monomers. Indomethacin and Alendronate(ALD) were added to the PNIPAm gels and CaP microspheres for release, respectively. When the temperature rises (above the lower critical solution temperature-LCST), the polymer gel shrinks, squeezing the drug into the porous. ALD into the CaP microspheres was slowly diffuses than Indomethacin into the PNIPAm because coated SiO2 and PNIPAm. PNIPAm/SiCaP microspheres were characterized by Fourier transform infrared (FT-IR), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and thermal gravimetric analysis (TGA). Drug release of thermo-responsive microspheres was investigated by ultraviolet-visible (UV) spectrophotometry.

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