abs

학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Catalytic Enantionselective Cyclic Reactions of Diazoacetates

등록일
2012년 2월 23일 14시 21분 24초
접수번호
1431
발표코드
ORGN.O-7 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 11시 : 32분
발표형식
구두발표
발표분야
유기화학 - Oral Presentation for Young Organic Chemists
저자 및
공동저자
gaolizhu, 류도현
성균관대학교 화학과, Korea

1, 3- Dipolar cycloadditions between diazocompounds and activated olefins or acetylenes have been extensively investigated and are presently well understood but, there has been little work reported on 1, 3-dipolar additions with substituted acroleins. Catalytic synthetic approach to get the highly functionalized pyrazolines was investigated. In the presence of chiral (S)-oxazaborolidinium ion as catalyst, the reaction proceeded with high to excellent enantioselectivities (up to 99 % ee). Enantioselective cyclopropanation reactions via Michael- initiated ring closure between diazoacetates and alpha,beta-unsaturated aldehydes are highly desirable as the corresponding cyclopropanes containing two or more electron-withdrawing groups can be valuable synthetic intermediates for various applications. In the presence of chiral (S)-oxazaborolidinium cation as catalyst, catalytic synthetic approach to get the highly functionalized cyclopropane was investigated. Reactions proceeded in high yield (up to 93%) with high to excellent diastereoselectivity (up to 98% de) and enantioselectivity (up to 95% ee).


상단으로