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제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Enhancing cysteine selectivity over glutathione in thiol-sensing

등록일
2012년 2월 23일 14시 23분 40초
접수번호
1432
발표코드
BIO.P-701 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
강철훈, 한지혜1, 허경준, 김진영2
경희대학교 동서의학대학원, Korea
1경희대학교 동서의학대학원 의과학전공, Korea
2경희대학교 동서의학대학원/의과학과, Korea
A series of the position isomers its benzoic acid moiety of a coumarine structure (1) to enhance cysteine selectivity in thiol-sensing is currently under characterization. 1 can react with some biological thiols (Cys, and GSH) to emit fluorescence at 513nm with 480nm excitation, which is used for characterization of its thiol reactivity. At pH 7.4 in an aqueous solution, The order of the rate constant is Cys >> GSH, and the ratio of the rate constant for Cys to that for GSH is found to be highest for the ortho isomer. The associative equilibrium constants for the reaction of the ortho isomer to Cys is much higher than that to GSH. The order of them along with its isomeric position for both is para > meta > ortho. These data indicate that, to achieve the best enhancement of Cys selectivity, the position for the carboxylic group in 1 is the ortho position. Such preference for the ortho position may be caused by repulsive electrostatic interaction between the carboxylate and the additional negative change on GSH compared to Cys.

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