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학술발표회초록보기

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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Separation and Analysis of Peptide by Capillary Electrophoresis Directly Coupled to Desorption Electrospray Ionization Mass Spectrometry

등록일
2012년 2월 23일 16시 51분 08초
접수번호
1485
발표코드
ANAL.P-643 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
분석화학
저자 및
공동저자
안지용, 이용일, 임재민
창원대학교 화학과, Korea
Capillary electrophoresis (CE) separation technique is more efficiency than usual high-performance liquid chromatography (HPLC). The CE coupled to conventional electrospray ionization mass spectrometer (ESI-MS) offer the ability to separate, chemically identify, and provide structural information on analytes in small sample volumes. It is usually carried out using electrospray ionization. However, the salts and detergents used in the mobile phase for CE separations suppress ionization efficiencies and contaminate the inlet of the mass spectrometer. This study describes a new method that uses a CE directly coupled to desorption electrospray ionization (DESI) to overcome these limitations. Collected sample from CE is deposited on a DESI plate that is heated with electric heating coil. As the surface moves, surface-deposited analytes are ionized by DESI and then detected by MS. And several important experimental parameters influencing CE-DESI-MS were optimized by that uses angiotensin ll. At no distant date, CE-DESI-MS will be able to analyse several complex glycoproteins, such as fetuin.

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