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학술발표회초록보기

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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Studying Structures and Conformation Dynamics of Proteins Using Spectrometric Analysis

등록일
2012년 2월 29일 00시 16분 34초
접수번호
1515
발표코드
ANAL1-8 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 17시 : 00분
발표형식
분과기념
발표분야
분석화학 - Recent Advances in Analytical Chemistry I
저자 및
공동저자
김준곤
포항공과대학교 화학과, United States
In this presentation, we provide our on-going studies of structural dynamics of proteins using supramolecular chemistry and spectrometric techniques. Cucurbit[6]uril (CB[6]) and 18-crown-6 (18C6) are neutral cyclic molecules, which are efficient host molecules in molecular recognition and have high affinity for positively charged or cationic compounds. We have investigated the host-guest chemistry of CB[6] and 18C6 to lysine residues of proteins and its applications to study protein structure dynamics using various spectrometric techniques including mass spectrometry, ion mobility mass spectrometry, circular dichroism spectrometry, and fluorescence spectrometry. For example, the propensity of a series of isobaric poly-alanine based peptides with a Lys to form a helix in the gas phase is improved via host-guest chemistry with 18C6. Low energy collision induced dissociation of a CB[6]-protein complex yields highly selective fragments and additional MSn spectra reveal details of the CB[6] binding sites, which allow us to deduce the protein structures and their population in the solution phase. Further applications of supramolecular chemistry related to controlling protein structure dynamics will be discussed.

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