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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Solid Phase approach for the synthesis of 2-amido oxadiazole

2012년 2월 29일 12시 31분 49초
ORGN.O-13 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 12시 : 48분
유기화학 - Oral Presentation for Young Organic Chemists
저자 및
이상협, BALAJI1
대구가톨릭대학교 생명화학과, Korea
1대구가톨릭대학교 화학과, India

New synthetic methods for solid-phase synthesis are the powerful technique in generating combinatorial libraries of small molecules. Parallel solid phase synthesis is a valuable alternative to traditional synthesis. Solid phase synthesis is the technique where molecules are temporarily bound by solid support in order to streamline the synthesis process. Advantages include easy removal of excess of reactants and by products via washing and filtration. Heterocycles are the single most important class of organic compounds which possess the wide range of biological and industrial applications. Pharmaceutical, agrochemicals and cosmetic industries are using the different heterocyclic compounds by changing the structural features. The wide spread use of 1,3,4-oxadiazole as a core of the large number of therapeutic area, such as anti-bacterial, anti-fungal, anti-miotic, anti-inflammatory, anti-hypertensive, HIV integrase inhibitor and the angiogenesis inhibitors. They also used as intermediate for preparation of various biologically active compounds. As a part of our ongoing work in the development novel polymer supported catalyst, reagents and polymer supported synthesis of small drug molecules. Therefore, herein we developed the new procedure for the synthesis of 1,3,4-oxadiazole using hydroxyl methyl Janda Jel linker. In the present investigation we introduced the use of polymer bound benzyolhydrazinecarbaxylate, from which the respective targets were generated by cyclo-dehydration and smart cleavage reaction to increase the diversity of the scaffold.