New synthetic methods for solid-phase synthesis are the powerful technique in generating combinatorial libraries of small molecules. Parallel solid phase synthesis is a valuable alternative to traditional synthesis. Solid phase synthesis is the technique where molecules are temporarily bound by solid support in order to streamline the synthesis process. Advantages include easy removal of excess of reactants and by products via washing and filtration.
Heterocycles are the single most important class of organic compounds which possess the wide range of biological and industrial applications. Pharmaceutical, agrochemicals and cosmetic industries are using the different heterocyclic compounds by changing the structural features. The wide spread use of 1,3,4-oxadiazole as a core of the large number of therapeutic area, such as anti-bacterial, anti-fungal, anti-miotic, anti-inflammatory, anti-hypertensive, HIV integrase inhibitor and the angiogenesis inhibitors. They also used as intermediate for preparation of various biologically active compounds.
As a part of our ongoing work in the development novel polymer supported catalyst, reagents and polymer supported synthesis of small drug molecules. Therefore, herein we developed the new procedure for the synthesis of 1,3,4-oxadiazole using hydroxyl methyl Janda Jel linker. In the present investigation we introduced the use of polymer bound benzyolhydrazinecarbaxylate, from which the respective targets were generated by cyclo-dehydration and smart cleavage reaction to increase the diversity of the scaffold.