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학술발표회초록보기

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제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Effect of Anti Cancer Organic Molecule(Apoptozole) Targeted to Hsp70

등록일
2012년 2월 29일 12시 44분 13초
접수번호
1521
발표코드
BIO.P-709 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
고성균, 신인재
연세대학교 화학과, Korea
The inducible Hsp70 is known to act as anti-apoptotic factor to protect cells from apoptosis induced by various stressful stimuli. This chaperone protein is highly expressed in many cancer cells and its overexpression correlates with tumor development and resistance to chemotherapy. In this study, we present evidence that apotozole (Az) inhibits Hsp70 activity by binding to its ATPase domain and this binding leads to blocking the interaction of Hsp70 with Apaf-1, thereby inducing apoptosis. However, Az neither suppresses the interaction of Hsp70 with apoptopsis inducing factor (AIF) nor influences the expression levels of Hsp70 and other apoptosis-related proteins such as Apaf-1, caspases and AIF. These results suggest that apoptosis induced by Az may take place via caspase activation processes. Interestingly, treatment of cancer cells with combination of apoptozole and doxorubicin enhanced apoptosis in comparison with single treatment with doxorubicin. These findings suggest that apoptozole has a potential of being used as an antitumor agent or combination with other anticancer agents.

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