abs

학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Development of Biocompatable Materials for siRNA Delivery Systems

등록일
2012년 2월 29일 14시 39분 41초
접수번호
1529
발표코드
ORGN.P-962 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
박정우, 박유진, 김병현
포항공과대학교 화학과, Korea
Small interfering RNA (siRNA) has been applied for gene therapy as a powerful tool. siRNA can recognize and silence complementary sequence of target mRNA in the cell and inhibit the target protein expression. Even though siRNA has great therapeutic potential, application of siRNA still has several problems such as cytotoxicity, low cellular uptake, poor target specificity, and weak nuclease resistance. Among the most interesting siRNA delivery systems are peptide-based gene delivery systems. In general, peptide-based delivery exhibits no or low toxicity toward cells or tissues because peptides are common in our bodies and rarely induce immune responses. To overcome the obstacles of siRNA therapy, we used two types of delivery systems. One is peptide-siRNA conjugation method. In this method, various peptides are introduced to the siRNA by using covalent bonds such as a disulfide bond. The other is peptide-siRNA complexation methods using electrostatic interaction between siRNA and peptide. We will discuss the physical and biological properties of both systems and their transfection activities towards various cells.

상단으로