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학술발표회초록보기

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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Functionalized Chiral Porous MOFs as a Mimic and Compilation of Enzyme Active Sites

등록일
2012년 3월 1일 13시 02분 44초
접수번호
1544
발표코드
ORGN2-2 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 15시 : 00분
발표형식
심포지엄
발표분야
유기화학 - Current trends in Organic Chemistry: catalysis, structure and function
저자 및
공동저자
정낙철
고려대학교 화학과, Korea
Chiral metal?organic frameworks (MOFs), which can be assembled using a modular approach with chiral organic links and metal ions, are of interest for applications in enantioselective separation and catalysis being especially important for the chemical and pharmaceutical industries. Conceptually, these materials are envisioned as a compilation of enzyme active sites if the pores bear the proper functionality. We have designed and synthesized a chiral metal?organic framework, (S)-KUMOF-1 (Cu2(S)-1)2(H2O)2,1 ¼ 2,20-dihydroxy-6,60-dimethyl(1,10-biphenyl)-4,40-dicarboxylate) of which a non-interpenetrating NbO type framework provides a spacious pore (2 _ 2 _ 2 nm3) and is equipped with potential catalytic sites exposed into the pore. With this in hand, we were able to delineate an underlying principle in building up a practically useful chiral MOF with reasonable size of cavities. And also, an unambiguous evidence for that the reactions took place inside the structure was obtained. More details of fundamental issues will be illustrated with a couple of reactions, the carbonyl-ene reaction and hetero Diles-Alder reaction.

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