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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Ionic Surfactant-Coated Burkholderia Cepacia Lipase as the Highly Active Catalyst in Organic Solvent

등록일
2012년 3월 1일 15시 45분 50초
접수번호
1551
발표코드
ORGN.P-966 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
오연옥, 이은경, 김만주
포항공과대학교 화학과, Korea

Biocatalysis is useful for organic synthesis. For example, lipase is a useful tool for the synthesis of optically active compounds such as chiral alcohols, acids, and their esters. However, lipase catalysis in organic solvent often suffers from reduced activity, selectivity, or stability of enzyme. Therefore, it is important to develop a strategy to improve the reaction performance of lipase in organic solvent. We have developed a highly active enzyme in organic solvent by coating Burkholderia cepacia lipase(BCL) with an ionic surfactant. Commercially available BCL(crude BCL) exhibits significantly lower activity than Candida antarctica lipase B(CALB; Novozym 435) for acylation of 1-phenylethanol in toluene. Fortunately, we have developed a practical approach for enhancing its activity dramatically. We have discovered that ionic-surfactant-coated Burkholderia cepacia lipase(ISCBCL) has great potential as such an excellent enzyme. It is “1000-fold more active” than crude BCL and “2-fold more active” than Novozym 435. The results indicate that ISCBCL is more efficient than Novozym 435 as the catalyst for the enzymatic reaction in organic solvent.


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