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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Small Molecules That Regulate Biological Processes

2012년 3월 8일 14시 39분 45초
ORGN1-4 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 10시 : 30분
유기화학 - KCS-RSC joint symposium- Chemical Biology
저자 및
Nur Elida M.Z, 신인재1, 김재호
아주대학교 분자과학기술학과, Korea
1연세대학교 화학과, Korea
Neurons are not regenerated effectively and their injury causes neurodegenerative diseases. These diseases may be treated by the transplantation of neurons derived from stem cells. However, ethical and technical issues restrict stem cell therapies. A more attractive approach is the use of small molecules with the capacity to induce neurogenesis from easily available cells or tissues. We discovered the first such molecule, neurodazine, identified by screening an imidazole library with C2C12 myoblasts. Further analyses show that neurodazine promotes the expression of neuron-specific markers in treated C2C12 cells. In addition, the use of neurodazines in conjunction with a microtubule-destabilizing agent allows neurogenic conversion of both differentiated immature myotubes and mature skeletal muscle. Apoptosis (or programmed cell death) is a fundamental biological process that regulates a variety of normal physiological processes. Since apoptosis is involved in both normal physiology and various human diseases, research on apoptosis has become a central area in basic biological studies and the development of therapeutic agents. We have identified a small molecule that interacts with Hsc70 and Hsp70. This small molecule induces apoptosis in cells and holds considerable potential as a powerful cancer therapeutic in addition to aiding our understanding of the molecular basis of Hsp70-related apoptotic processes. We have also developed a new chemical modulator that can help gain more detailed insight into heart development. This compound induces abnormal heart development, including the formation of pipe-like heart structures and enlarged pericardiac sacs. In this presentation, I will discuss our current progress of small molecules that affect cell differentiation and development.