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제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis of Kojic acid derivatives and evaluation of their biological activity

등록일
2014년 8월 28일 13시 58분 57초
접수번호
0924
발표코드
MEDI.P-957 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
김재관, 박정호1,*, 박경찬2, 신수정3, 김범철2, 장미3, HUMENGYANG4
한밭대학교 생유기화학실험실, Korea
1한밭대학교 응용화학생명공학부, Korea
2한밭대학교 생명공학과, Korea
3한밭대학교 응용화학과, Korea
4한밭대학교 응용화학, Korea
Kojic acid (KA) is produced by Aspergillus oryzae-sort of like mushrooms, which is commonly called as koji in Japan. KA is used as a chelation agent and a preservative preventing oxidative browning of fruits. KA also shows antibacterial and antifungal properties. Because KA stops the production of melanin by inhibiting tyrosinase in the biosynthetic pathway from tyrosine to melanin in skin, it has been applied as a skin lightening ingredient in cosmetics. Since some animal studies have shown that high amounts of KA had side effects such as in liver, kidney, reproductive, cardiovascular, gastrointestinal, respiratory, brain, and nervous system, more efficient KA derivatives are needed to be developed in order to safely apply as a skin lightening ingredient. A series of KA derivatives were synthesized and their in vitro tyrosinase inhibitory activities were evaluated. Specifically, the IC50 value of compound HBU-246 was 0.88±0.39 ?M against tyrosinase. It is about 50 times more effective tyrosinase inhibitor compared to KA itself (IC50 = 45.2±4.6 ?M).

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