In recent years, continuous flow microreactor have been recognized as powerful tools for chemical synthesis from the viewpoint of both academia and industry due to the advantages, such as (1) controlled heat transfer, (2) controlled mixing (both fast and slow) (3) increased solution-solid phase interactions (4) controlled use of high reactive materials, and (5) tailor-made reactor to run serial reactions. Unsymmetrical Ketones are useful compounds present in many area, including materials, fragrances, and natural product synthesis. Thus, a variety of methods for the preparation of ketones have been developed. However, to the best of our knowledge, direct addition of lithium species to acyl chlorides without any additives has not yet been reported using batch reactor.
Herein we report a new synthetic method for the synthesis of unsymmetrical ketones employing flow microreactor in the presence of acyl chlorides and in situ generated lithium species.