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114th General Meeting of Korean Chemical Society The development of drug delivery system combined convergence technology for conducting diagnostic and therapeutic inner ear diseases simultaneously

Submission Date :
8 / 28 / 2014 , 14 : 04 : 21
Abstract Number :
Presenting Type:
Poster Presentation
Presenting Area :
Authors :
김종혁, 주굉건1, 이재범2,*
부산대학교 인지메카트로닉스공학과, Korea
1부산대학교 나노융합기술대학, Korea
2부산대학교 나노메디컬공학과, Korea
Assigned Code :
MAT.P-1096 Assigend Code Guideline
Presenting Time :
10월 15일 (수요일) 16:00~19:00
Using general diagnostic criteria, the diagnosis of Meniere’s disease have been hard to receive definite diagnosis. Assessing the symptoms of Meniere’s disease is difficult due to similar other ear disease and lack of a gold standard. In order to improve diagnostic challenge, recent studies focus on the use of magnetic resonance imaging (MRI) after intratympanic gadolinium injection to monitor inner ear in vivo. And intratympanic gentamicin treatment (ITG) is effective to relieve severe episodic vertigo but optimal dose and period of administration have been ambiguous. For optimal protocol, we synthesize hollow silica nanoparticles (HSNPs) loaded gentamicin and gadolinium based contrast agent simultaneously. Utilizing HSNs, we can monitor gentamicin efficacy real time by aid of gadolinium based contrast agent. HSNPs were characterized by X-ray diffraction (XRD), transmission electron microscope (TEM), thermo gravimetric analyzer (TGA) and N2 adsorption-desorption isotherms.