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제114회 대한화학회 학술발표회, 총회 및 기기전시회 Synthesis of Cyclosophoraose-β-Cyclodextrin Heterodimer as a Novel Complexation Agent

등록일
2014년 8월 28일 15시 10분 29초
접수번호
1052
발표코드
ANAL.P-549 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
분석화학
저자 및
공동저자
정다함, 윤덕규, 정재필1, 정선호2,*
건국대학교 생명공학과, Korea
1건국대학교 특성화학부, Korea
2건국대학교 특성화학부 생명공학과, Korea

Cyclosophoraoses (Cys) produced from Rhizobium species are cyclic β-(1,2)-glucans containing between 17 and 23 glucose units, and β-Cyclodextrin (βCD) is a seven-membered cyclic β-(1,4)-glucan produced from starch by enzymatic conversion. They are known as a useful complexation agent for various application fields. In this study, the novel Cys-βCD heterodimer was synthesized by mono tosyl-Cys (Ts-Cys) reacting with mono ethylenediamine modified βCD (EtβCD) and mono ethylenediamine modified Cys (EtCys) reacting with mono tosyl-βCD (Ts-βCD). The yield of TS-Cys reacting with EtβCD is 10 times higher than Et-Cys reacting with Ts-βCD. We isolated and purified the Cys-βCD heterodimer by cationic exchange and size exclusion chromatographic techniques. Its structure was confirmed via nuclear magnetic resonance (NMR) spectroscopy and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry analysis. Since the Cys-βCD heterodimer has two different cavities or complexation ability, it is expected as an efficient host for chemo-sensors and solubility/bioavailability enhancer of natural compounds comparing with the original βCD and Cys.


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