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제114회 대한화학회 학술발표회, 총회 및 기기전시회 Differentiated Recognition of Structural Isomers α and β-Naphthoflavone by Synthesized β-cyclodextrin Dimers

2014년 8월 28일 15시 14분 24초
ANAL.P-553 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 15일 (수요일) 16:00~19:00
저자 및
최재민, 정다함, Jae-Hyuk Yu1, 정선호2,*
건국대학교 생명공학과, Korea
1University of Wisconsin, Madison, U.S.A., United States
2건국대학교 특성화학부 생명공학과, Korea
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승인 1건

The structural isomers of α and β-naphthoflavones have distinctive functions with small structural differences. β-cyclodextrin dimers has been investigated for recognizing the structural isomer α and β-naphthoflavones. The differentiated recognizing ability of β-cyclodextrin dimers toward α and β-naphthoflavones was monitored by UV vis spectrometry. Because of the distinguished association of naphthoflavone isomers with β-cyclodextrin dimers, the solubility enhancement efficiency of two naphthoflavones by β-cyclodextrin dimers showed huge difference. In the presence of by β-cyclodextrin dimer, the solubility of α-naphthoflavones was increased 26 fold of its native solubility whereas the solubility of β-naphthoflavone dramatically increased up to 469 fold. The physicochemical properties of α and β-naphthoflavones and their carbohydrate complexes were characterized by Fourier-transform infrared spectra and differential scanning calorimetry. Scanning electron microscopy data showed the morphological structure changes of native α and β-naphthoflavones and their complex with novel carbohydrate-solubilizers. Based on these results, β-cyclodextrin dimer successfully recognizes structural isomer α and β-naphthoflavones and is also able to form an efficient complex with α and β-naphthoflavones, suggesting the potential usage of β-cyclodextrin dimer as isomer separating agent.