abs

학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 09월 04일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis and antiproliferative activity of 3,5-Disubstituted indole

등록일
2014년 8월 28일 15시 17분 24초
접수번호
1072
발표코드
MEDI.P-966 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
MORE KUNAL, HONG VICTOR SUKBONG, 이진호*
계명대학교 화학과, Korea
Pim kinase is a family of kinase comprising of highly homologus members as Pim-1,2 and 3, encoding for serine/threonine specific kinases. This enzyme is linked to many cell functions as cell growth, differentiation, proliferation and apoptosis. Deregulated Pim kinase expression or over expression may lead to many cancers as colon, pancreatic, and prostate cancer. Thus Pim kinases are very promising targets for the treatment of cancers. 3,5-Disubstituted indole alkaloids have been reported to have inhibitory activity against protein kinases including Pim kinases. Based on the previous results, we synthesized a novel series of compounds bearing 2-aminopyrimidine at 3- and 5-position of indole. Structure activity relationship was studied by modifying the substituent at 6-position of 2-aminopyrimidine attached at 5-position of indole. Compound 6c found to be potent to all three isoformes of Pim kinase. It selectively inhibits Pim kinase among panel of 14 protein kinase. Also compound 6c showed dose-dependent inhibition in leukemic cell lines.

상단으로