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제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Liposome distruption by dimeric β-cyclodextrin studied with polydiacetylene colorimetric vesicles

등록일
2014년 8월 28일 15시 26분 08초
접수번호
1091
발표코드
ANAL.P-559 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
분석화학
저자 및
공동저자
조은애, 최재민1, 정다함1, 전봉현1, 정선호2,*
건국대학교 유비쿼터스정보기술연구원, Korea
1건국대학교 생명공학과, Korea
2건국대학교 특성화학부 생명공학과, Korea

Dimeric β-cyclodextrins (β-CD) were synthesized by the reaction of native β-CD with epichlorohydrin under basic conditions. We have investigated the effects of dimeric β-CD on the diacetylene and polydiacetylene liposomes. The vesicular diacetylene was distrupted in the presence of dimeric β-CD with the consequent inhibition of polymerization. The result might be attributed to the formation of a complex between dimeric β-CD and diacetylene liposomes, and it was clearly differentiated from that of monomeric β-CD. Furthermore, the ordered supramolecular structure of polydiacetylene was perturbed by the dimeric β-CD, which was detected from the visible color change. Finally, the morphological characteristics and size of polydiacetylene in the absence and presence of dimeric β-CD were examined using transmission electron microscopy and dynamic light scattering. The results show fused structure of size more than 200 nm along with the deformation of the vesicles, and they represent a novel phenomenon of liposome structure induced by complexation with dimeric β-CD. The evaluated physicochemical characteristics can be applied to the development of carbohydrate-based surfactants.


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