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114th General Meeting of Korean Chemical Society Liposome distruption by dimeric β-cyclodextrin studied with polydiacetylene colorimetric vesicles

Submission Date :
8 / 28 / 2014 , 15 : 26 : 08
Abstract Number :
114082810918
Presenting Type:
Poster Presentation
Presenting Area :
분석화학
Authors :
조은애, 최재민1, 정다함1, 전봉현1, 정선호2,*
건국대학교 유비쿼터스정보기술연구원, Korea
1건국대학교 생명공학과, Korea
2건국대학교 특성화학부 생명공학과, Korea
Assigned Code :
ANAL.P-559 Assigend Code Guideline
Presenting Time :
10월 15일 (수요일) 16:00~19:00

Dimeric β-cyclodextrins (β-CD) were synthesized by the reaction of native β-CD with epichlorohydrin under basic conditions. We have investigated the effects of dimeric β-CD on the diacetylene and polydiacetylene liposomes. The vesicular diacetylene was distrupted in the presence of dimeric β-CD with the consequent inhibition of polymerization. The result might be attributed to the formation of a complex between dimeric β-CD and diacetylene liposomes, and it was clearly differentiated from that of monomeric β-CD. Furthermore, the ordered supramolecular structure of polydiacetylene was perturbed by the dimeric β-CD, which was detected from the visible color change. Finally, the morphological characteristics and size of polydiacetylene in the absence and presence of dimeric β-CD were examined using transmission electron microscopy and dynamic light scattering. The results show fused structure of size more than 200 nm along with the deformation of the vesicles, and they represent a novel phenomenon of liposome structure induced by complexation with dimeric β-CD. The evaluated physicochemical characteristics can be applied to the development of carbohydrate-based surfactants.