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학술발표회초록보기

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결제문의 member@kcsnet.or.kr

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  • 09월 04일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Studies on the solvent-free synthesis of β-lapachone through the acid-mediated intramolecular cyclization of lapachol

등록일
2014년 8월 28일 15시 29분 54초
접수번호
1098
발표코드
ORGN.P-850 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
이현진, 이고은1, 김학원*
경희대학교 응용화학과, Korea
1경희대학교 일반대학원 화학과, Korea

β-Lapachone (β-LAPA), is a chemotherapeutic agent derived from the bark of the South American Lapacho tree, has recently emerged as a potent antitumor, anti-virus, anti-parasitic, and anti-inflammatory agent in vitro, and in vivo. Among previously known synthetic methods, C-prenylation of lawsone to give lapachol and the subsequent intramolecular cyclization of lapachol under strong acid condition, such as sulfuric acid and trifluoromethanesulfonic acid have been well known. However, C-prenylation of lawsone gave many side products to result in low yield and the following strong acid-mediated intramolecular cyclization yielded hazardous wastes and then it could not be suitable for industrial-scale production. Hence, in order to synthesize β-lapachone in high yield with mild, easy to handle, and environmentally-friendly reagents we have tried to develop much better and the greener process of intramolecular cyclization using recyclable solid-supported acid, such as inorganic supports(Alumina, silica, clays, zeolite) or organic supports(Polymer resins, cellulose) acid or solid acid in the absence of solvent.


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