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학술발표회초록보기

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  • 09월 04일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Highly Efficient Solvent-free Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles and their Evaluation

등록일
2014년 8월 28일 15시 30분 02초
접수번호
1099
발표코드
ORGN.P-851 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
노경탁, 허남회1, 김학원2,*
경희대학교 화학과, Korea
1서강대학교 화학과, Korea
2경희대학교 응용화학과, Korea

1,3,4-Oxadiazole is considered as very important compounds due to their biological and medicinal activities, fluorescent and corrosion inhibition properties which has led lots of efforts to develop new methodologies for the preparation of various oxadiazoles. Recently, tremendous efforts in the organic synthesis field have been devoted to reduce costs and resources consuming via environmentally benign, simple, and practical processes. In this report, a mild, general, convenient and efficient one-pot synthesis of symmetrical and unsymmetrical 1,3,4-oxadiazoles from hydrazide through N-acylhydrazones is described. Several hydrazides were efficiently grinded with various aldehydes by using ball-mill machine to give the corresponding N-acylhydrazones. Resulting N-acylhydrazones underwent a smooth BTI[bis(trifluoroacetoxy)iodobenzene]-mediated cyclization reaction in the absence of solvent to afford symmetrical and unsymmetrical 1,3,4-oxadiazoles in good yields. It would be developed for a sustainable organic synthetic process. Resulting 1,3,4-oxadiazoles have been investigated for the fluorescence properties and metal complexation. Those would be used for fluorescence chemosensor or OLED materials.


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