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학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

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제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Identification of Natural Product Inhibitors for CDC25 Phosphatases

등록일
2014년 8월 28일 15시 42분 03초
접수번호
1122
발표코드
BIO.P-636 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
박기선, 강효진, 정상전*
동국대학교 화학과, Korea
Cell division cycle 25 (Cdc25) homologs are dual specificity phosphatases that dephosphorylate both a serine/threonine and a tyrosine side chain of protein substrates. Cdc25 phosphatases also play a critical role in the cell cycle progression by activating kinase of Cdk/cyclin complexes. The human Cdc25 family are composed of three members: Cdc25A, B, and C. Overexpression of Cdc25s results in cell cycle progression, which causes head, colon, and breast cancers. In addition, high expression level of the proteins has been implied to correlate with either a poor prognosis or aggressiveness of tumor. Consequently, discovery of selective Cdc25s inhibitors may be a starting point to develop anticancer therapy. We have screened 658 member of purified natural compounds for inhibition of purified Cdc25s to identify hit compounds for each enzyme. Furthermore, we determined IC50 and Ki values of the hits for the enzyme inhibition, and proposed the inhibitor-binding pockets on the enzymes through docking simulation.

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