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학술발표회초록보기

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제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 A “Light-up” silver ion sensing of peptide amphiphile nanoprobe and its biological applications

등록일
2014년 8월 28일 15시 43분 11초
접수번호
1125
발표코드
ORGN.P-856 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
김인혜, 김용재, 이나은, 허강무1, 이은지*
충남대학교 분석과학기술학과, Korea
1충남대학교 고분자공학과, Korea
Herein, peptide amphiphiles consisting of a hydrophobic alkyl chain (linear for PA 1 or branched type for PA 2) and hydrophilic histidine-containing peptide, which is known to detect specific metal ions, self-assembled into nanofibers (NFs) in water with a strong aggregation tendency. Particularly, by adopting pyrene as a fluorescent probe, the self-aggregate behavior was investigated based on different optical properties between PA 1 and 2. Furthermore, PA 1 shows light-off sensing signal to Cu2+ while PA 2 increases the fluorescence by capturing Ag+ in aqueous solution. Also, a considerable enhancement of fluorescence in Ag+-NF-loaded HeLa cells was observed. In addition, the NFs of PA 2 decorated with AgNFs are shown to possess highly effective and long-term antibacterial activity against both Gram-negative and -positive bacteria. This interesting interaction between Ag+ and PA 2 makes it possible for the biological application of cell-imaging and antimicrobial agents.

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