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제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Facile Synthesis of N-Methylated Amino Acids from Chiral Aziridine-2-carboxylate

등록일
2014년 8월 28일 15시 44분 42초
접수번호
1129
발표코드
ORGN.P-857 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
최지혜, 하현준*, 이원구1,*
한국외국어대학교 화학과, Korea
1서강대학교 화학과, Korea

N-methylated amino acids attract attentions due to their metabolic stability and conformational rigidity compared to their counter amino acids. Furthermore, many peptides consisted of N-methylated amino acids showed distinctive properties for the application of drug development and of novel materials. However, only limited numbers of N-methylated amino acids are commercially, most of which are quite expensive. Though various synthetic methods have been developed for the preparation of N-methylated amino acids an efficient and generally applicable protocol toward them is still needed. Recently, we reported “N-methylative aziridine ring opening reaction” of non-activated aziridines. Herein we described an efficient preparation of N-methylated amino acid by N-methylative aziridine ring opening reaction of aziridine-2-carboxylate and carboxamide with various nucleophiles including OAc?, OH?, N3?, CN? to yield N-methylated α- or β-amino acids.


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