Recently, Keyzers at al. reported firstly bioassay-guided isolation of a new 1-deoxysphingoid, 3-epi-Xestoaminol C, isolated from the New Zealand brown alga Xiphophora chondrophylla. This compound as a stereoisomer of xestoaminol C show IC50 value of 19.4, 8.8 and 18.0 μM against M. tuberculosis H36Ra, HL-60 cells, and HEK cells, respectively. Any synthesis of 3-epi-Xestoaminol C has been not reported since its isolated from organism, structural confirmation of identified molecule through synthesis is important. We achieved efficient and asymmetric synthesis of 3-epi-Xestoaminol C and xestoaminol C using synthetic strategy previously developed by us to make sure the configuration of 3-epi-Xestoaminol C and xestoaminol C efficiently.
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