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제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Quantitative dissection of RNA polymerase-controlled gene expression variability [우수포스터상]

등록일
2014년 8월 28일 15시 54분 00초
접수번호
1161
발표코드
PHYS.P-441 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
물리화학
저자 및
공동저자
임유림, 김지현, 성재영*
중앙대학교 화학과, Korea
Transcriptional initiation, at the end of which RNA polymerase (RNAP) is ready to synthesize a mRNA molecule, is an important regulatory step for downstream gene expression. The question of how noise in intracellular RNAP level is propagated into the downstream gene network has attracted experimental and theoretical interests. Here, we present how to quantitatively understand the effect of RNAP-promoter interaction fluctuation on the gene expression statistics. By making use of the fact that various moments characterizing the downstream gene expression statistics are essentially a function of the mean and noise of RNAP level, as was recently found for synthetic E. coli with T7 RNAP transcritpion machinery, we introduce the non-perturbative method to efficiently take into account the effect of the higher-order moments of RNAP-promoter interaction fluctuation. The resulting analytic expressions provide a quantitative explanation of the mean and noise of protein level. Furthermore, we could explain that the susceptibility of the protein noise to the RNAP noise decreases with RNAP level while the normalized correlation between RNAP and protein levels increases.

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