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학술발표회초록보기

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  • 09월 04일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Exploring New Ligand Designs for Asymmetric Catalysis

등록일
2014년 8월 28일 15시 56분 19초
접수번호
1167
발표코드
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발표시간
목 15시 : 30분
발표형식
심포지엄
발표분야
무기화학 - Organometallics: New Trends in Catalysis
저자 및
공동저자
홍석원
광주과학기술원(GIST) 신소재공학부, Korea

Chiral cooperative catalysis enabling simultaneous activation of both an electrophile and a nucleophile has emerged as a powerful strategy in catalytic asymmetric synthesis. In our laboratory, a series of novel hydrogen-bond functionalized salen-transition metal catalysts have been developed to facilitate bimetallic or bifunctional activation of both reaction partners. For example, a self-assembling dinuclear Co(II)-salen catalyst featuring the pyridone/aminopyridine H-bonding pair results in significant rate acceleration as well as excellent enantioselectivity in nitro-aldol reaction. Bis-urea functionalized salen-Co(III) complexes exhibited significant rate acceleration in hydrolytic kinetic resolution of epoxides even at low catalyst loading (0.05 mol%). The bis-urea salen-Co(III) complexes are also excellent catalysts for anti-selective asymmetric Henry reaction where broad substrate scope, good yield, excellent enantio- and diastereoselectivity were observed. During this presentation, synthesis of ligands/catalysts, applications in asymmetric transformations, and plausible mechanisms will be discussed in detail.


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