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제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Hydrophobicity of Amino Acids in Protein Context

등록일
2014년 8월 28일 16시 08분 10초
접수번호
1196
발표코드
PHYS.P-444 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 15일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
물리화학
저자 및
공동저자
임해리, 정성호, 함시현*
숙명여자대학교 화학과, Korea
Hydrophobicity is a major driving force in protein folding, protein self-assembly and protein-ligand interaction. Moreover, hydrophobicity is the key point to understand the role of water in protein interaction. Commonly, protein hydrophobicity is evaluated as a sum of hydrophobicity scales for component amino acids, and it is based upon the premise that the hydrophobicity scales determined for individual free amino acids have not changed when amino acids are embedded in a protein. Here, we investigate how the hydrophobicity of amino acids depends on the protein context by computing the solvation free energy (SFE) of a protein and by decomposing it into contributions from constituent amino acids. We find that the negatively charged residues show decreased SFE and the positive ones show increased SFE when the protein total charge is negative, whereas this trend is reversed when the protein total charge is positive.

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