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  • 09월 04일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Nucleic Acid Conjugates for Biomedical Applications

2014년 9월 2일 14시 44분 08초
BIO2-3 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 14시 : 30분
생명화학 - Biological Chemistry of Nucleic Acid and Its Derivatives
저자 및
건국대학교 특성화학부, Korea
Nucleic acids have been used as informative building blocks to allow superior biomedical applications like drug delivery, biosensors, and imaging. Through complementary hybridization, ligation, and chemical conjugation, diverse geometric structures have been created in a micro- and nanoscale. In this presentation, several bio-conjugates based on nucleic acids, particularly short chain RNAs like small interfering RNA (siRNA) and microRNA (miRNA), will be covered. Short chain RNAs are biological molecules which possess great potential not only as regulators of translation but also as therapeutics of diseases like cancers and genetic disorders. One of big challenges in RNA therapeutics is still delivery efficiency. This presentation will outline recent results related to delivery of short chain RNAs. Multivalent aptamer-RNA conjugates will be discussed as an simple, efficient, and targeted delivery systems for siRNAs into target cancer cells. Those multivalent aptamer-RNA conjugates were shaped like a rod with high aspect ratios, which exhibited greatly enhanced intracellular delivery for target cancer cells compared to common Aptamer-siRNA conjugates. It is likely that multivalent ligands of the Comb-type aptamer siRNA conjugates allowed efficient internalization via clustering effects. In addition, delivered Comb-type aptamer siRNA conjugates successfully suppressed target genes and reduced cancer cell proliferation. The newly designed bio-conjugates might have great potential to serve as a carrier for intracellular delivery of short chain RNAs.