Pd-catalyzed cycloreduction of enediynes affording the [m,5,n]-tricyclic compounds indeed proceeds with high levels of chemo- and stereo-selectivities. And Pd-catalyzed cycloreduction of enediynes is accompanied by a significant increase in structural complexity.
Many alcohol derivatives of Capnellene have demonstrated potential as a chemotherapeutic agent with antibacterial, anti-inflammatory and anti-tumor properties. Because of these reasons, capnellene has been targeted for synthesis by numerous investigators.
We used this method to synthesize triquinane natural product, (±)-Ceratopicanol and we are applying this enediyne cycloreduction method to Δ9,12-capnellene synthesis. Our synthesis involves Pd-catalyzed cycloreduction of enediyne 1 in order to construct the tricyclic framework 2.