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제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Cellular responses by particulate matter in human respiratory epithelial cells

2014년 9월 3일 15시 47분 57초
BIO.P-652 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 15일 (수요일) 16:00~19:00
저자 및
허남, 김동은*
건국대학교 생명공학과, Korea
Particulate matter (PM) is one of the most common ambient air pollutants, which is derived from diesel engine, wildfires, yellow dust, and other combustion sources. In general, size of the PM determines the negative effect on human health. Recently, PM-caused risks of damaging respiratory organs including lung disease are increasing every year. Autophagy and apoptosis are cellular responses to nutritional deficiencies and/or degradation of dysfunctional proteins, which is necessary for maintaining of cellular homeostasis. Previous studies have reported that PM-induced autophagy and apoptosis has been considered as an important molecular mechanism of PM-mediated cytotoxicity in lung cancer epithelial cells. In this study, we investigated effect of particulate matter (PM2.5) on cellular responses in human respiratory epithelial primary cells. The epithelial cells showed decrease of cell viability when exposed to PM in a time and dose dependent manner. In addition to onset of autophagy via increase of LC-3 (microtubule-associated protein light chain-3) puncta, PM treatment increases expression of inflammatory cytokine, tumor necrosis factor-α (TNF- α) in human respiratory epithelial primary cells. Thus, inflammation response as well as autophagosome formation were induced for survival of respiratory epithelial primary cells under challenge of PM.