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  • 09월 04일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제114회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Development of Fluorescent Chalcone-mimicking Probes for the Detection of β-amyloid Plaques in the Brain from Alzheimer's Diesease

2014년 9월 3일 17시 30분 39초
MEDI.P-975 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 15일 (수요일) 16:00~19:00
저자 및
정승진, 김보람1, 이상윤2, 박정훈1, 허민구1, 양승대1, 박용대1,*
한국원자력연구소 방사선 기기연구부 (정읍), Korea
1한국원자력연구원 방사선기기연구부, Korea
2동국대학교 신소재화학과, Korea
Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by cognitive decline, irreversible memory loss, disorientation, and language impairment. The formation and deposition of β-amyloid (Aβ) plaques consisting mainly of Aβ peptides in the brain is now considered one of the most significant factors in AD. Currently, the definitive diagnosis of AD is dependent on only the histopathological examination of Aβ plaques in the postmortem brain. Therefore, in vivo imaging of Aβ plaques in the living brain may lead to the early detection of AD or monitoring the progression and effectiveness of novel treatments that are currently being investigated. In this study, we synthesized two chalcone-mimicking probes (9 and 10) and evaluated their fluorescent characterization and biological activities with Aβ aggregates. Two probes exhibited a approximately 50-fold increase of emission spectra after mixing with Aβ aggregates. The binding affinities for Aβ aggregates were shown as the KD value (1.59 for 9 and 2.30 for 10). We also investigated their neuropathological staining of Aβ plaques in transgenic mouse (APP/PS1) brain sections. The results suggest that chalcone derivatives have high binding affinities for amyloid plaques in transgenic mice brain, as reflected by an in vitro binding assay using Aβ aggregates may be more useful for presymptomatic and the early detection of AD pathology.