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제118회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Highly branched carbohydrate-bearing amphiphiles for membrane protein research

등록일
2016년 8월 29일 11시 26분 50초
접수번호
2107
발표코드
ORGN2-1 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 09시 : 00분
발표형식
심포지엄
발표분야
유기화학 - Current Trends in Organic Chemistry Ⅱ: Molecular Recognition
저자 및
공동저자
채필석
한양대학교 생명나노공학과, Korea
Detergents are amphipathic chemicals essential for membrane protein study. Conventional detergents are widely used, but many membrane proteins surrounded by these agents tend to undergo denaturation/aggregation, leading to structural degradation and functional loss. Recently, based on detergent design principles established in our group, we have developed several classes of novel amphiphiles to overcome the limitations of conventional detergents. Among these agents, we introduce here penta-saccharide-bearing amphiphiles (PSA/Es) bearing the new hydrophilic group where a glucose core is radially surrounded by four glucose units. These agents were remarkably capable of retaining the native structures of multiple membrane proteins including a G protein-coupled receptor (GRCR) as compared to DDM. Some representatives were also effective at stabilizing beta2AR-G protein complexes, enabling us to visualize the individual subunits of the complexes via single-particle electron microscopy. Therefore, these agents will find wide utility in membrane protein research.

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