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제118회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Ferric Ion Accumulation in the Walls of Metabollically Dormant Saccharomyces cerevisiae Cells as Another Form of Iron Storage

2016년 8월 30일 09시 54분 48초
INOR.P-246 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 13일 (목요일) 11:00~12:30
저자 및
박진규*, Paul A. Lindahl1
한국원자력연구원 원자력화학연구부, Korea
1Texas A&M University, U.S.A., Korea
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승인 1건
Iron (Fe) is an essential element for cellular metabolism playing numerous roles in enzyme catalysis, electron transfer processes, and small-molecule binding and activation, etc. On the other hand, Fe can also be detrimental to the cell, because certain forms participate in Fenton chemistry generating reactive oxygen species (ROS) which can thus damage DNA, proteins, and membranes. Hence, the trafficking and regulation of Fe are remarkably important in cellular metabolism. Mitochondria, Golgi apparatus and endoplasmic reticulum are known to be crucial Fe regulatory organelles and vacuoles are major storage for intracellular Fe. In this study, Fe in Saccharomyces cerevisiae cell was monitored by biophysical and bioanalytical tools such as Mossbauer and electron paramagnetic resonance spectroscopy and inductively-coupled plasma mass spectrometry, while the cells were grown to metabolically dormant status. It turned out that the cells accumulate Fe in the cell walls mainly in the form of mononuclear nonheme high-spin Fe (III). When the dormant cells were incubated in a fresh but Fe-deficient medium, cells were able to grow using the accumulated Fe, indicating that the cell walls might function as an Fe storage. More details will be discussed in the presentation.