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학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

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  • 09월 01일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제118회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Single molecule picking and quantification of biomarkers with AFM

등록일
2016년 8월 30일 16시 13분 52초
접수번호
2182
발표코드
INOR1-4 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 14시 : 55분
발표형식
심포지엄
발표분야
무기화학 - Recent Trends in Inorganic Chemistry I: Symposium for Senior Professors
저자 및
공동저자
박준원
POSTECH 화학과, Korea
Self-assembly of dendrons provided nano-spacing between reactive functional groups on surface. The spacing guarantees the freedom of biological macromolecules so that their properties are close to that in solution in spite of the confinement in the two dimensional space. Such surface modification was integrated with atomic force microscopy (AFM) and the approach enabled new applications. For the DNA-DNA interaction, both binding and unbinding events were observed, and guaranteed single molecular interaction was a key advantage from the controlled surface. In particular, the mapping capability of AFM enabled us to see various biomarkers (DNA, mRNA, microRNA, antigen, and antibody) captured on surface. In particular, fabricating a tiny spot (a few microns in diameter) of the capture probe enhanced the detection limit dramatically. In this talk, both single molecule manipulation and quantification of biomarkers with AFM will be introduced.

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