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  • 09월 01일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제118회 대한화학회 학술발표회, 총회 및 기기전시회 안내 pH-Responsive DNA-Driven Au Nanomachine for Combinational Cancer Therapeutics

2016년 8월 31일 15시 13분 48초
MAT.P-617 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 14일 (금요일) 11:00~12:30
저자 및
박형목, 김진환, 김원종*
POSTECH 화학과, Korea
Owing to the sequence specific hybridization, DNA has attracted enormous attention as a programmable and predictable building block for dynamic nanomachine. We present herein a pH-responsive multifunctional Au nanomachine operated by functional DNA for combined chemo-, phototheraml, and photodynamic therapy. To achieve that, pH-responsive DNA sequence, known as i-motif, was grafted on the surface of gold nanoparticle by gold-thiol interaction. By employing the fact that the anticancer drug, doxorubicin (DOX), easily intercalates on duplex DNA, the Au nanomachine was exploited for DOX delivery carrier. Once this nanoparticle is internalized into the cells, endosomal acidic pH induces the dehybridization of i-motif and its complementary sequence, and subsequently DOX was released from duplex structure. Because i-motif DNAs on the gold nanoparticle bind to nearby i-motif DNAs on another one, gold nanoparticles were aggregated to bigger particles, which enable the photothermal therapy when NIR light was subjected. As well, a photosensitizer was selectively loaded on the specific DNA sequence for photodynamic therapy. Taken all together, combinatorial effect of chemo-, photothermal, and photodynamic therapy was evaluated at the cellular level in a synergistic manner. The dynamic nanomachine developed herein would provide a simple way to design a combinational cancer therapeutic system.