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  • 09월 01일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제118회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Copper-Catalyzed N-Arylation of 2-Pyridones Employing Diaryliodonium Salts at Room Temperature

등록일
2016년 9월 1일 12시 47분 07초
접수번호
2343
발표코드
ORGN.P-428 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 14일 (금요일) 11:00~12:30
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
정서희, 김원석*
이화여자대학교 화학 나노과학과, Korea
N-aryl heterocycles have attracted synthetic organic chemists due to their intriguing biological activities. In particular, N-aryl pyridine-2(1H)-one is an important moiety present in biological active compounds such as Pirfenidone, Perampanel and Amphenidone. Therefore, numerous synthetic methods have been reported to form C-N bond between 2-pyridones and either aryl halides or aryl boronic acids as a coupling partner. Herein, a mild and efficient method for the synthesis of N-aryl pyridine-2(1H)-one is demonstrated by using various diaryliodonium salts as an electrophilic coupling partner at room temperature. Most reactions proceed readily at room temperature in the presence of 10 mol% of copper chloride. As a result, a wide range of N-aryl pyridine-2-ones were synthesized in yields of 23% to 99%. We have also investigated the synthesis of Pirfenidone which was successfully synthesized in 99% yield within 30 min at room temperature.

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