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학술발표회초록보기

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  • 09월 01일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제118회 대한화학회 학술발표회, 총회 및 기기전시회 안내 A new class of tripodal glucose-cored amphiphiles (TGAs) for membrane protein study

등록일
2016년 9월 1일 14시 02분 30초
접수번호
2367
발표코드
ORGN.P-432 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 14일 (금요일) 11:00~12:30
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
EHSANMUHAMMAD, 채필석1,*
한양대학교 바이오나노공학과, Pakistan
1한양대학교 생명나노공학과, Korea
Most membrane proteins exist in complexes with other proteins rather than isolated entities. To fully understand their biological functions it is essential to study the intact membrane protein assemblies. The overexpression and purification of many membrane protein complexes is still a considerable and unsurmountable challenge. In the case of membrane protein complex, thus, protein extraction from a source as a large multi-subunit cellular complex is necessary for the structural analysis. Detergents are indispensable tools in the isolation of membrane protein complexes from the biological membranes for downstream characterization. Here, we designed a glucose-cored family of detergents containing tripodal hydrophobic group. These novel agents were evaluated for a set of membrane proteins including a G-protein coupled receptor (GPCR). Among all of them, TGA-E8 displayed favorable behaviors for all targeted membrane proteins, indicating that this TGA has a significant potential in membrane protein structural study.

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