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  • 09월 01일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제118회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Dynamic Nanostructures Fabricated from DNA Block Copolymers

등록일
2016년 9월 1일 14시 49분 24초
접수번호
2385
발표코드
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발표시간
목 14시 : 00분
발표형식
심포지엄
발표분야
고분자화학 - Nucleic Acids in Materials Science – Programmable Biopolymers
저자 및
공동저자
박소정*, Qingjie Luo1
이화여자대학교 화학나노과학과, Korea
1University of Pennsylvania, China
※ 국외소속으로 등록된 저자의 승인여부는 최소 3일이내 발표자 email로 알려드립니다.
승인 1건
Here, we present active DNA nanostructures fabricated through the self-assembly of DNA block copolymers. A DNA diblock copolymer of polymethylacrylate-block-DNA (PMA-b-DNA) were synthesized and co-assembled with a prototypical amphiphilic polymer of poly(butadiene)-block-poly(ethylene oxide) (PBD-b-PEO).1 The binary self-assembly of PMA-b-DNA and PBD-b-PEO resulted in giant polymersomes with DNA uniformly distributed in the hydrophilic PEO shell. When giant polymersomes were connected through specific DNA interactions, DNA block-copolymers migrated to the junction area, forming DNA islands within polymersomes. These results indicate that DNA hybridization can induce effective lateral polymer segregation in mixed polymer assemblies. The polymer segregation and local DNA enrichment has important implications in DNA melting properties, as mixed block copolymer assemblies with low DNA block copolymer contents can still exhibit useful DNA melting properties that are characteristic of DNA nanostructures with high DNA density. The presentation will also discuss ways to prepare shape-changing dynamic nanostructures through DNA-based self-assembly.

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