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  • 09월 01일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제118회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Continuous-Flow Hydrogenation of Nitroarenes Using Magnetic Pd-Pt-Fe3O4 Nanoflakes

2016년 9월 1일 15시 18분 10초
ORGN.P-434 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
10월 14일 (금요일) 11:00~12:30
저자 및
김홍원, 김성민, 박진균*
부산대학교 화학과, Korea

Continuous-flow reaction technique for organic synthesis has many advantages when compared to batch reaction. Safer reactions could be ensured when handling hazardous chemicals because the flow reaction of small amounts of materials enables easy mixing and heat control. Furthermore, gas evolution with high pressure could be easily controlled by a back pressure regulator (BPR). Therefore, flow reaction technique has already been demonstrated that fine chemicals, such as natural products or active pharmaceutical ingredients could be scaled up in academia as well as in pharmaceutical industry. One of the types of continuous flow systems is immobilizing catalyst in the continuous reactor which we are interested in. Recently, Kim et al. has reported the preparation of magnetic bimetallic Pd-Pt-Fe3O4 NPs, which exhibited as efficient heterogeneous catalyst for the reduction of nitroarene using ammonia-borane as reducing agent at room temperature. Magnetic bimetallic catalyst was easily recycled more than 200 times using an external magnet, however, we thought that it would be more beneficial if the catalyst could be applied in flow for the continuous production of the desired product. Also, we considered ammonia-borane a very practical reagent for the continuous reaction because of its high stability and good solubility in organic solvent. Finally, we have demonstrated the easy reversible fixation of Pd-Pt-Fe3O4 nanoflakes in tubing using neodymium magnet and reduced nitroarenes to anilines using ammonia borane. Under the optimized continuous-flow hydrogenation protocols, a variety of nitroarenes were tolerated with excellent yields.