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  • 09월 01일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제118회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Tandem neopentyl glycol-based maltosides with a short linker for analysis of membrane proteins

등록일
2016년 9월 1일 14시 52분 03초
접수번호
2392
발표코드
ORGN.P-435 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 14일 (금요일) 11:00~12:30
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
배형은, 채필석1,*
한양대학교 바이오나노학과, Korea
1한양대학교 생명나노공학과, Korea
Membrane proteins are main players for many cellular functions. Research on membrane proteins has brought significant attention in scientific community. However, membrane protein research is tremendously difficult mainly due to their inherent amphipathic characteristic. Accordingly, many membrane proteins have strong tendency to aggregate and denature in an aqueous solution. Amphipathic molecules called detergents are widely used as essential tools to solve the issues associated with membrane protein analyses. However, conventional detergents often have serious limitation at maintaining protein activity in a sufficiently long term for protein structural determination. In the present study, we synthesized four tandem neopentyl glycol-based maltosides with a short linker, designated TNM-Ss, and characterized their micellar properties. When evaluated with a few membrane proteins, these agents displayed favorable behaviors compared to conventional detergents for the proteins targeted here.

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