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  • 09월 01일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제118회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Palladium-Catalyzed Direct Arylation of [1,2,4]triazolo[1,5-a]pyridines at the C5 and C8 position

등록일
2016년 9월 1일 16시 21분 46초
접수번호
2421
발표코드
ORGN.P-436 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 14일 (금요일) 11:00~12:30
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
박선영, 박진균*
부산대학교 화학과, Korea
[1,2,4]Triazolo[1,5-a]pyridines are one of the typical kinds of fused N-heterocyclic compounds. They have frequently been used in pharmaceuticals, herbicides, fluorescent brighteners, electronic materials.1,2 Especially, C5 substituted [1,2,4]triazolo[1,5-a]pyridines are important structural motif such as DNA-dependent protein kinase, stabilizing agents for photographic emulsions, antibacterial agents, selective adenosine receptor antagonists and several inhibitors, such as PDE inhibitors, selective JAK1 inhibitors, and TGFβ receptor inhibitors.3 And C8 substituted [1,2,4]triazolo[1,5-a]pyridines are utilized for electronic devices. Despite their clear importance, installation of an aryl group at the C5 and C8 positions of triazolopyridine still remains a challenge and only achieved via conventional multi-step process.4 From the perspective of atom and step economy, the development of direct arylation would be attractive for rapid and systematic generation of useful heterocycles. Herein, we will present a new method for direct syntheses of C-5 and C-8 substituted [1,2,4]triazolo[1,5-a]pyridines using a Pd catalyst.

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