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학술발표회초록보기

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  • 09월 01일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제118회 대한화학회 학술발표회, 총회 및 기기전시회 안내 1D Supramolecular Nanoplatform for Theranostics Based on Co-Assembly of Bioactive Amphiphiles

등록일
2016년 9월 1일 15시 42분 10초
접수번호
2422
발표코드
POLY.P-95 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 13일 (목요일) 11:00~12:30
발표형식
포스터
발표분야
고분자화학
저자 및
공동저자
김인혜, 이은지*
충남대학교 분석과학기술학과, Korea
A simple strategy for the preparation of multifunctional nanoparticles with potential diversification is presented using aqueous self-assembly of peptide amphiphiles (PAs) with precisely designed block. Versatile, one-dimensional (1D) supramolecular nanoplatform for personalized needs, particularly – theranostics, was fabricated by co-assembly of each functional PA, compensating for time-consuming and inaccessible chemical synthesis. Each PA was tagged with tumor cell-targeting peptide or was conjugated with ligand for paramagnetic metal ion (Gd3+) for magnetic resonance (MR) imaging, respectively. The two PA types were co-assembled to integrate each PA function into the original 1D nanotemplates. Fibrils, driven by the assembly of PA with hydrophobic β-sheet–forming peptide block, were also utilized as a nanotemplate for drug loading within their robust core. The resulting 1D nano-aggregates allowed successful intracellular delivery of doxorubicin (DOX) to target cancer cells and contrast-enhanced MR imaging by high longitudinal (T1) relaxivity of water protons. Correlation between the structural nature of fibrils formed by PA co-assembly and its diagnostic efficacy was elucidated. The co-assembly of PAs with desirable functions may thus be a useful strategy for the generation of tailor-made biocompatible nanomaterials.

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